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The reversal of a hyperglycemic, hyperosmolar, nonketotic coma secondary to TPN requires the administration of:

  • Anticoagulants
  • Histamine blockers
  • Insulin
  • Sodium lactate
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In the case of a hyperglycemic, hyperosmolar, nonketotic coma secondary to TPN (total parenteral nutrition), the administration of insulin is necessary to reverse the condition. Insulin helps to lower blood glucose levels and promote the uptake of glucose by cells, thus improving the hyperglycemia. It also helps to prevent the production of ketones and corrects the imbalance in electrolytes caused by the hyperosmolarity. Anticoagulants, histamine blockers, and sodium lactate are not directly involved in the treatment of this condition, making insulin the correct answer.

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